Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection.
Virus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication Door Shelf Hole Cover compartments (RC) during the early stages of HSV-1 infection.Between 2 and 3 hours post infection at a MOI of 10, host protein quality control machinery such as molecular chaperones (e.g.Hsc70), the 20S proteasome and ubiquitin are reorg